Dapagliflozin Online



How and where to order Dapagliflozin (Farxiga, Forxiga) 5 mg, 10 mg tablets online:

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Type:Dapagliflozin, Farxiga, Forxiga brand and generics
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Forxiga, Farxiga (Dapagliflozin)Dapagliflozin (trade names include Forxiga, Farxiga, Forziga, Edistride, Oxra) is an antidiabetic medication from sodium-glucose co-transporter 2 (SGLT2) inhibitors pharmacological groups. This medicine is used for the treatment of diabetes type 2 or noninsulin-dependent diabetes as an adjunct to diet and exercise to improve glycemic control, to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors, to reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure with reduced ejection fraction (NYHA class II-IV). It works by lowering the level of the blood sugar by removing the excess sugar from the body through the urine. Forxiga and Farxiga can be used alone or in combination with other anti-diabetic medicines such as metformin or saxagliptin.


Related medications:

  • Actos (Pioglitazone)
  • Amaryl (Glimepiride)
  • Avandia (Rosiglitazone)
  • Byetta (Exenatide)
  • Empagliflozin (Empagliflozin)
  • Galvus (Vildagliptin)
  • Glucophage (Metformin)
  • Glucotrol (Glipizide)
  • Glyburide (Glibenclamide)
  • Glyset (Miglitol)
  • Gondafon (Glymidine)
  • Invokana (Canagliflozin)
  • Januvia (Sitagliptin)
  • Onglyza (Saxagliptin)
  • Prandin (Repaglinide)
  • Precose (Acarbose)
  • Qtern (Dapagliflozin, Saxagliptin)
  • Victoza (Liraglutide)
  • Voglib (Voglibose)
  • Xigduo-XR (Dapagliflozin, Metformin)


    Pharmacological and medical categories:

  • Antidiabetic drugs
  • Blood glucose lowering agents
  • Medications for the therapy of diabetes type 2
  • Oral anti-diabetic medications
  • SGLT-2 inhibitors


    ATC codes:

  • A - Alimentary tract and metabolism
  • A10 - Drugs used in diabetes
  • A10B - Blood glucose lowering drugs, excl. insulins
  • A10BK - Sodium-glucose co-transporter 2 (SGLT2) inhibitors
  • A10BK01 - Dapagliflozin


    ICD-10 codes:

  • Type 2 diabetes mellitus - E11
  • Heart failure - I50


    Indications and usage:

    Farxiga and Forxiga (Dapagliflozin Propanediol Monohydrate) tablets for oral use is a sodium-glucose cotransporter 2 (SGLT2) inhibitor indicated in adults for:

    Type 2 Diabetes Mellitus:

  • as an adjunct to diet and exercise to improve glycemic control.
  • to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors.

    Heart Failure:

  • to reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure with reduced ejection fraction (NYHA class II-IV).

    Limitations of use:

    Not for treatment of type 1 diabetes mellitus or diabetic ketoacidosis.


    Dosage and administration:

    Assess renal function before initiating and then as clinically indicated.

    Type 2 Diabetes Mellitus:

  • To improve glycemic control the recommended starting dose is 5 mg once daily, taken in the morning. Increase dose to 10 mg once daily in patients tolerating 5 mg who require additional glycemic control.
  • To reduce the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors, the recommended dose is 10 mg once daily.
  • Dapagliflozin is not recommended for glycemic control when the eGFR is less than 45 mL/min/1.73 m2.

    Heart Failure:

    The recommended dose of Farxiga tablets is 10 mg once daily.


    Dosage forms and strengths:

  • Farxiga (Dapagliflozin Propanediol Monohydrate) tablets 5 mg and 10 mg.
  • Forxiga (Dapagliflozin Propanediol Monohydrate) tablets 5 mg and 10 mg.


    Overdosage:

    There were no reports of overdose of dapagliflozin during the clinical development program for Farxiga. In the event of an overdose, contact a local poison control center. It is also reasonable to employ supportive measures as dictated by the patient's clinical status. The removal of dapagliflozin by hemodialysis has not been studied.


    Contraindications:

  • History of serious hypersensitivity reaction to Farxiga (Dapagliflozin).
  • Severe renal impairment (eGFR less than 30 mL/min/1.73 m2) in patients who are being treated for glycemic control without established cardiovascular disease or cardiovascular risk factors.
  • Patients on dialysis.


    Warnings and precautions:

  • Volume depletion: Before initiating Farxiga, assess volume status and renal function in the elderly, patients with renal impairment or low systolic blood pressure, and in patients on diuretics. Monitor for signs and symptoms during therapy.
  • Ketoacidosis in patients with diabetes mellitus: Assess patients who present with signs and symptoms of metabolic acidosis for ketoacidosis regardless of blood glucose level. If suspected, discontinue Dapagliflozin, evaluate and treat promptly. Before initiating Farxiga, consider risk factors for ketoacidosis. Patients on Farxiga (Dapagliflozin) may require monitoring and temporary discontinuation of therapy in clinical situations known to predispose to ketoacidosis.
  • Urosepsis and pyelonephritis: Evaluate for signs and symptoms of urinary tract infections and treat promptly, if indicated.
  • Hypoglycemia: Consider a lower dose of insulin or the insulin secretagogue to reduce the risk of hypoglycemia when used in combination with Farxiga.
  • Necrotizing fasciitis of the perineum (Fournier's gangrene): Serious, life-threatening cases have occurred in patients with diabetes, both females and males. Assess patients presenting with pain or tenderness, erythema, or swelling in the genital or perineal area, along with fever or malaise. If suspected, institute prompt treatment.
  • Genital mycotic infections: Monitor and treat if indicated.


    Side effects, adverse reactions:

    The most common adverse reactions associated with Dapagliflozin tablets (Farxiga, Forxiga), 5% or greater incidence, were female genital mycotic infections, nasopharyngitis, and urinary tract infections.

    To report suspected adverse reactions, contact AstraZeneca company or a local FDA.


    Drug interactions:

    Positive urine glucose test

    Monitoring glycemic control with urine glucose tests is not recommended in patients taking SGLT2 inhibitors as SGLT2 inhibitors increase urinary glucose excretion and will lead to positive urine glucose tests. Use alternative methods to monitor glycemic control.

    Interference with 1,5-anhydroglucitol (1,5-AG) assay

    Monitoring glycemic control with 1,5-AG assay is not recommended as measurements of 1,5-AG are unreliable in assessing glycemic control in patients taking SGLT2 inhibitors. Use alternative methods to monitor glycemic control.


    Use in specific populations:

  • Pregnancy: Advise females of the potential risk to a fetus especially during the second and third trimesters.
  • Lactation: Farxiga (Dapagliflozin) is not recommended when breastfeeding.
  • Geriatrics: Higher incidence of adverse reactions related to hypotension.
  • Renal impairment: Higher incidence of adverse reactions related to hypotension and renal function.


    Pregnancy categories:

  • B - Australia
  • C - United States (Risk cannot be ruled out)


    Salts and other forms:

  • Dapagliflozin Base
  • Dapagliflozin Propanediol
  • Dapagliflozin Propanediol Anhydrous
  • Dapagliflozin Propanediol Hydrate
  • Dapagliflozin Propanediol Monohydrate
  • Dapagliflozin Propylene Glycolate Hydrate
  • Dapagliflozin, mixture with Propylene Glycol, Hydrate


    Synonyms, international and chemical names:

  • Dapagliflozina
  • Dapagliflozine
  • Dapagliflozinepropaandiol
  • Dapagliflozini
  • Dapagliflozinum
  • Dapaglyflozin


    Brands, generics, trade names:

  • Edistride - AstraZeneca
  • Farxiga - AstraZeneca
  • Forxiga - AstraZeneca
  • Forziga - AstraZeneca
  • Oxra - Sun Pharmaceutical Industries, Bhagwati Pharma & Surgicals


    APIs used in medicine in combinations with dapagliflozin:

  • Metformin
  • Saxagliptin


    Here is a list of popular medications containing dapagliflozin as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Edistride
  • Tablets, Film-Coated; Oral; Dapagliflozin Propanediol Monohydrate 5 mg
  • Tablets, Film-Coated; Oral; Dapagliflozin Propanediol Monohydrate 10 mg
  • AstraZeneca
  • Associated Drug Co.
  • Bristol-Myers Squibb
  • Dr. Esteve Laboratorios
  • TAU Laboratorio
  • Vistor
  • Farxiga
  • Tablets, Film-Coated; Oral; Dapagliflozin Propanediol Monohydrate 5 mg
  • Tablets, Film-Coated; Oral; Dapagliflozin Propanediol Monohydrate 10 mg
  • AstraZeneca
  • Forxiga
  • Tablets, Film-Coated; Oral; Dapagliflozin Propanediol Monohydrate 5 mg
  • Tablets, Film-Coated; Oral; Dapagliflozin Propanediol Monohydrate 10 mg
  • AstraZeneca
  • Anugerah Pharmindo Lestari
  • Associated Drug Co.
  • Bristol-Myers Squibb
  • DKSH Distribution
  • Four Star
  • Vistor
  • Zuellig Pharma



  • References:

  • Dapagliflozin main article on Wikipedia: https://en.wikipedia.org/wiki/Dapagliflozin
  • Dapagliflozin compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin
  • Dapagliflozin Propanediol compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin-propanediol
  • Dapagliflozin Propanediol Anhydrous compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin-propanediol-anhydrous
  • Dapagliflozin Propanediol Monohydrate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin-propanediol-monohydrate
  • Dapagliflozin Propylene Glycolate Hydrate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin-propylene-glycolate-hydrate
  • Dapagliflozin on DrugBank: https://www.drugbank.ca/drugs/DB06292
  • Dapagliflozin Propanediol Monohydrate on DrugBank: https://www.drugbank.ca/salts/DBSALT001101
  • Dapagliflozin FAQ on MedlinePlus: https://medlineplus.gov/druginfo/meds/a614015.html
  • Farxiga (Dapagliflozin) tablets film-coated drug label info on DailyMed: https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Dapagliflozin containing drugs on Drugs-About.com: https://drugs-about.com/ing/dapagliflozin.html
  • Dapagliflozin for sale on Pharma Doctor: https://pharma-doctor.com/dapagliflozin.html
  • Dapagliflozin international drug names on Drugs.com: https://www.drugs.com/international/dapagliflozin.html
  • Farxiga (Dapagliflozin) tablets for oral use official prescribing information and medication guide from the U.S. FDA: https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Farxiga (Dapagliflozin) 5 mg, 10 mg tablets prescribing information from AstraZeneca pharmaceutical company: https://medicalinformation.astrazeneca-us.com/home/prescribing-information/farxiga-pi.html
  • Farxiga (Dapagliflozin) official website: https://www.farxiga.com/
  • Farxiga (Dapagliflozin) official website for US Health Care Professionals: https://www.farxiga-hcp.com/
  • Forxiga (Dapagliflozin Propanediol Monohydrate) tablets 5 mg and 10 mg product monograph from AstraZeneca: https://www.astrazeneca.ca/content/dam/az-ca/downloads/...
  • Forxiga (Dapagliflozin Propanediol Monohydrate) tablets official prescribing and product information from the Australian Government Department of Health: https://www.ebs.tga.gov.au/ebs/picmi/...
  • Forxiga (Dapagliflozin Propanediol Monohydrate) tablets consumer medicine information from the Australian Government Department of Health: https://www.ebs.tga.gov.au/ebs/picmi/...
  • Forxiga (Dapagliflozin) 5 mg film-coated tablets package information leaflet on Medicines.org.uk: https://www.medicines.org.uk/emc/files/pil.2865.pdf
  • Forxiga (Dapagliflozin) 10 mg film-coated tablets package information leaflet on Medicines.org.uk: https://www.medicines.org.uk/emc/files/pil.7607.pdf

    Updated: September 2020
    Reviewed: September 2020



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